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ZETA USA| Products | Freeze & Thaw
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Freeze & Thaw Systems

Controlled freezing, storage, and thawing systems for sensitive biologics.
Engineered to maintain product stability during storage, transport, and process transitions.
Discuss Your Freeze & Thaw Process
The image shows a person in protective clothing and blue gloves working with shiny metal equipment. They’re handling a red hose connected to pipes and valves. It looks like a clean, controlled setting for manufacturing or lab work.
The image shows a close-up of a shiny metal tank with pipes and fittings on top. A metal plate on the tank reads “ZETA.”

Preserving stability between production steps. Bridging time and distance in biopharma.

Biopharmaceutical production often requires intermediate storage or transport between manufacturing steps, facilities, or geographic locations. For sensitive biologics such as proteins, antibodies, and enzymes, maintaining product stability during these periods is critical.

Freezing provides a reliable method for preserving biological activity while minimizing degradation and microbial growth. However, freezing and thawing are complex physical processes. Ice formation, cryoconcentration, and temperature gradients can influence product stability and process performance.

Technology for critical freezing and thawing steps. Systems designed to protect sensitive biologics.

ZETA Freeze & Thaw Systems provide controlled freezing, storage, transport, and thawing of sensitive biopharmaceutical substances such as proteins, antibodies, and other biologics.

The systems combine mobile stainless-steel vessels with sophisticated refrigeration and temperature control technology. This architecture enables reliable freezing and thawing cycles while maintaining product integrity. In addition to production-scale equipment, ZETA provides laboratory and pilot-scale systems that support QbD-compliant and PAT-ready development of freezing processes, enabling reliable scale-up from development through commercial manufacturing.

Engineered for controlled freezing performance. Process stability through precise thermal management.

Automated Control

Controlled freezing and thawing profiles ensure reproducible process conditions.

Efficient Heat Transfer

Homogeneous temperature distribution supports consistent freezing and thawing performance.

Gentle Freezing

Freezing and thawing without agitation helps protect sensitive biologic products.

Process Development Support

Product-specific freezing processes can be developed and optimized.

Process Insights

ZETA FreezeSimulation tools support process design and freezing behavior prediction.

Freeze & Thaw Product Family

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ZETA FreezeContainers

Stainless-steel vessels for passive or active freezing.

Sizes available:

  • Passive freezing: 10 ml – 5000 ml
  • Active freezing: 10 – 300 L
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ZETA FreezeController

Automated temperature control unit for precise freezing and thawing cycles.

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ZETA FreezeSystem

Production-scale freezing, storage, and thawing system for biopharmaceutical manufacturing environments.

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ZETA LabFreeze System

Laboratory-scale system for early-stage freezing studies and formulation evaluation.

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ZETA PilotFreeze System

Miniature industry-grade freezing system used to simulate and validate freezing processes before production scale.

The image shows a shiny metal tank with pipes, valves, and gauges attached to the top. It’s mounted on a frame and labeled “ZETA.” The image shows a person in protective clothing working with industrial equipment. They’re using a tablet near an open control panel full of wires and electronics. Next to them is a large metal tank with pipes and valves. The image shows two pieces of industrial equipment made of shiny metal. One is a control unit with a screen and buttons, including an emergency stop. The other is a large tank with pipes and valves. Both are labeled “ZETA” and used in clean, precise manufacturing settings. A shiny, rectangular metal device with a clear window in the middle is shown. It has two round knobs on one side and tubes connected at the top. A person in a white lab coat and blue gloves is working with a shiny metal device labeled
The image shows a person in protective clothing working with industrial equipment. They’re using a tablet near an open control panel full of wires and electronics. Next to them is a large metal tank with pipes and valves.

Storage and transport of bulk biologics

Supporting flexible biopharma manufacturing

Freeze & thaw systems therefore play an important role in:

  • bulk drug substance (BDS) storage
  • transport between manufacturing sites
  • intermediate storage between upstream and downstream operations
  • stability management for temperature-sensitive biologics

By maintaining controlled freezing and thawing conditions, manufacturers can preserve product quality while enabling flexible production scheduling and global distribution.

ZETA Freeze & Thaw Systems provide a controlled and scalable solution for storing, transporting, and recovering frozen biologics within GMP manufacturing environments.

Freeze process development and scale-up. A structured approach.

Freezing processes must be carefully developed to maintain product stability and process consistency. ZETA supports this through a scalable development platform that enables freezing processes to be studied, optimized, and validated before implementation at production scale.

Typical development steps include:

Laboratory studies

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Using LabFreeze systems to investigate product stability, freezing behavior, and potential risks such as cryoconcentration or denaturation.

Pilot-scale validation

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Using PilotFreeze equipment to simulate production conditions and refine operating parameters.

Process simulation

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With FreezeSimulation tools to model temperature profiles and freezing dynamics.

Production implementation

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Using industrial FreezeSystems for controlled freezing, storage, transport, and thawing.

Protect Product Integrity Through Every Freeze & Thaw Cycle

Controlled freezing and thawing systems engineered for reliable handling of sensitive biopharmaceutical materials.
Discuss Your Freeze & Thaw Process
Person working with Freeze and Thaw System at ZETA

Advancing Freeze & Thaw Technology

How innovation and process understanding drive better outcomes.

From water-free thawing concepts to refrigerant-free freezing technologies, ongoing research at the ZETA TechCenter is helping shape the next generation of freeze and thaw solutions. Explore how process development, experimental studies, and engineering innovation support safer, more sustainable, and scalable biopharmaceutical manufacturing.

Read the Technical Article

Related Resources Freeze & thaw systems.

Freeze & Thaw Systems
Controlled freeze and thaw systems for the safe storage, transport, and handling of sensitive biopharmaceutical products across development and production environments.

Freeze Container Technical Data Sheet
Technical overview of GMP-compliant stainless steel FreezeContainers for active and passive freezing applications, including sizing, process conditions, and product handling capabilities.

Freeze & Thaw Services
Knowledge-based freeze and thaw process development services combining experimental studies, simulation, and scale-up support to improve protein stability and reduce product loss.
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